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KMID : 0366220140490020085
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Korean Journal of Hematology
2014 Volume.49 No. 2 p.85 ~ p.94
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Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants
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Nakashima Megan O.
Rogers Heesun J.
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Abstract
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Hypercoagulability can result from a variety of inherited and, more commonly, acquired conditions. Testing for the underlying cause of thrombosis in a patient is complicated both by the number and variety of clinical conditions that can cause hypercoagulability as well as the many potential assay interferences. Using an algorithmic approach to hyper-coagulability testing provides the ability to tailor assay selection to the clinical scenario. It also reduces the number of unnecessary tests performed, saving cost and time, and preventing potential false results. New oral anticoagulants are powerful tools for manag-ing hypercoagulable patients; however, their use introduces new challenges in terms of test interpretation and therapeutic monitoring. The coagulation laboratory plays an essen-tial role in testing for and treating hypercoagulable states. The input of laboratory pro-fessionals is necessary to guide appropriate testing and synthesize interpretation of results.
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KEYWORD
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Hypercoagulability, Algorithmic approach, Antiphospholipid syndrome, Direct oral anticoagulant, Venous thromboembolism
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